2024

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The role of exopolysaccharides Psl and Pel in resistance of Pseudomonas aeruginosa to the oxidative stressors

sodium hypochlorite and hydrogen peroxide.

da Cruz Nizer WS, Allison KN, Adams ME, Vargas MA, Ahmed D, Beaulieu C, Raju D, Cassol E, Howell PL, Overhage J.

Microbiol Spectr. 2024 Aug 28:e0092224. doi: 10.1128/spectrum.00922-24.

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Genetic determinants of increased sodium hypochlorite and ciprofloxacin susceptibility in Pseudomonas aeruginosa PA14 biofilms.

da Cruz Nizer WS, Adams ME, Montgomery MC, Allison KN, Beaulieu C, Overhage J.

Biofouling. 2024 Aug 27:1-17. doi: 10.1080/08927014.2024.2395378. 

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Draft genome sequence of a methicillin-resistant Staphylococcus aureus strain isolated from a chronic wound.

Allison KN, Mejlaoui R, DeZeeuw KG, Marek JE, Cassol E, Overhage J.

Microbiol Resour Announc. 2024 Aug 23:e0043124. doi: 10.1128/mra.00431-24.

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Oxidative stress responses in biofilms.

da Cruz Nizer WS, Adams ME, Allison KN, Montgomery MC, Mosher H, Cassol E, Overhage J.

Biofilm. 2024 May 23;7:100203. doi: 10.1016/j. bioflm.2024.100203.

 

2023

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The secondary metabolite hydrogen cyanide protects Pseudomonas aeruginosa  against sodium hypochlorite-induced oxidative stress.

da Cruz Nizer WS, Adams ME, Inkovskiy V, Beaulieu C, Overhage J.

Front Microbiol. 2023 Nov 16;14:1294518. doi: 10.3389/fmicb.2023.1294518.

Knock-out of multidrug efflux pump MexXY-OprM results in increased susceptibility to antimicrobial peptides in Pseudomonas aeruginosa.

Neidig A, Strempel N, Waeber NB, Nizer WSDC, Overhage J.

Microbiol Immunol. 2023 Sep;67(9):422-427. doi: 10.1111/1348-0421.13089.

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Synergy between Human Peptide LL-37 and Polymyxin B against Planktonic and Biofilm Cells of Escherichia coli and Pseudomonas aeruginosa.

Ridyard KE, Elsawy M, Mattrasingh D, Klein D, Strehmel J, Beaulieu C, Wong A, Overhage J.

Antibiotics (Basel). 2023 Feb 15;12(2):389. doi: 10.3390/antibiotics12020389.

 

2021

 

Oxidative Stress Response in Pseudomonas aeruginosa.

da Cruz Nizer WS, Inkovskiy V, Versey Z, Strempel N, Cassol E, Overhage J.

Pathogens. 2021 Sep 14;10(9):1187. doi: 10.3390/pathogens10091187.

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The Potential of Human Peptide LL-37 as an Antimicrobial and Anti-biofilm Agent.

Ridyard KE and J Overhage.

Antibiotics. 2021 May 29;10:650. doi: 10.3390/antibiotics10060650.

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Biofilm-Innate Immune Interface: Contribution to Chronic Wound Formation.

Versey Z, da Cruz Nizer WS, Russell E, Zigic S, DeZeeuw KG, Marek JE, Overhage J, Cassol E.

Front Immunol. 2021 Apr 9;12:648554. doi: 10.3389/fimmu.2021.648554. eCollection 2021.

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2020

 

Droplet-Microarray: Miniaturized Platform for High-Throughput Screening of Antimicrobial Compounds. 

Lei W, Demir K, Overhage J, Grunze M, Schwartz T, Levkin PA.

Adv Biosyst. 2020 Oct;4(10):e2000073. doi: 10.1002/adbi.202000073. Epub 2020 Sep 2.

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Surviving Reactive Chlorine Stress: Responses of Gram-Negative Bacteria to Hypochlorous Acid. 

da Cruz Nizer WS, Inkovskiy V, Overhage J.

Microorganisms. 2020 Aug 11;8(8):1220. doi: 10.3390/microorganisms8081220. Review.

 

The potential of drug repositioning as a short-term strategy for the control and treatment of COVID-19 (SARS-CoV-2): a systematic review.

Lima WG, Brito JCM, Overhage J, Nizer WSDC.

Arch Virol. 2020 Aug;165(8):1729-1737. doi: 10.1007/s00705-020-04693-5. Epub 2020 Jun 8.

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2018

 

Biomimetic 3D in vitro model of biofilm triggered osteomyelitis for investigating hematopoiesis during bone marrow infections. 

Raic A, Riedel S, Kemmling E, Bieback K, Overhage J, Lee-Thedieck C.

Acta Biomater. 2018 Jun;73:250-262. doi: 10.1016/j.actbio.2018.04.024. Epub 2018 Apr 19.

 

Novel roles for two-component regulatory systems in cytotoxicity and virulence-related properties in Pseudomonas aeruginosa.

Gellatly SL, Bains M, Breidenstein EBM, Strehmel J, Reffuveille F, Taylor PK, Yeung ATY, Overhage J, Hancock REW.

AIMS Microbiol. 2018 Mar 8;4(1):173-191. doi: 10.3934/microbiol.2018.1.173. eCollection 2018.

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2017

 

The Oxidative Stress Agent Hypochlorite Stimulates c-di-GMP Synthesis and Biofilm Formation in Pseudomonas aeruginosa. 

Strempel N, Nusser M, Neidig A, Brenner-Weiss G, Overhage J.

Front Microbiol. 2017 Nov 22;8:2311. doi: 10.3389/fmicb.2017.02311. eCollection 2017.

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A new data processing routine facilitating the identification of surface adhered proteins from bacterial conditioning films via QCM-D/MALDI-ToF/MS.

Hohmann S, Neidig A, Kühl B, Kirschhöfer F, Overhage J, Brenner-Weiß G.

Anal Bioanal Chem. 2017 Oct;409(25):5965-5974. doi: 10.1007/s00216-017-0521-5. Epub 2017 Aug 11.

 

The aliphatic amidase AmiE is involved in regulation of Pseudomonas aeruginosa virulence. 

Clamens T, Rosay T, Crépin A, Grandjean T, Kentache T, Hardouin J, Bortolotti P, Neidig A, Mooij M, Hillion M, Vieillard J, Cosette P, Overhage J, O'Gara F, Bouffartigues E, Dufour A, Chevalier S, Guery B, Cornelis P, Feuilloley MG, Lesouhaitier O.

Sci Rep. 2017 Jan 24;7:41178. doi: 10.1038/srep41178.

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2016

 

Enzyme-Mediated Quenching of the Pseudomonas Quinolone Signal (PQS) Promotes Biofilm Formation of Pseudomonas aeruginosa by Increasing Iron Availability.

Tettmann B, Niewerth C, Kirschhöfer F, Neidig A, Dötsch A, Brenner-Weiss G, Fetzner S, Overhage J.

Front Microbiol. 2016 Dec 9;7:1978. doi: 10.3389/fmicb.2016.01978. eCollection 2016.

 

Substrate specificity and function of acetylpolyamine amidohydrolases from Pseudomonas aeruginosa. 

Krämer A, Herzer J, Overhage J, Meyer-Almes FJ.

BMC Biochem. 2016 Mar 9;17:4. doi: 10.1186/s12858-016-0063-z.

PMID: 26956223 Free PMC article.

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2015

The absence of the Pseudomonas aeruginosa OprF protein leads to increased biofilm formation through variation in c-di-GMP level.

Bouffartigues E, Moscoso JA, Duchesne R, Rosay T, Fito-Boncompte L, Gicquel G, Maillot O, Bénard M, Bazire A, Brenner-Weiss G, Lesouhaitier O, Lerouge P, Dufour A, Orange N, Feuilloley MG, Overhage J, Filloux A, Chevalier S.

Front Microbiol. 2015 Jun 23;6:630. doi: 10.3389/fmicb.2015.00630. eCollection 2015.

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Synergistic effect of membrane-active peptides polymyxin B and gramicidin S on multidrug-resistant strains and biofilms of Pseudomonas aeruginosa.

Berditsch M, Jäger T, Strempel N, Schwartz T, Overhage J, Ulrich AS.

Antimicrob Agents Chemother. 2015 Sep;59(9):5288-96. doi: 10.1128/AAC.00682-15. Epub 2015 Jun 15.

 

Sensor kinase PA4398 modulates swarming motility and biofilm formation in Pseudomonas aeruginosa PA14. 

Strehmel J, Neidig A, Nusser M, Geffers R, Brenner-Weiss G, Overhage J.

Appl Environ Microbiol. 2015 Feb;81(4):1274-85. doi: 10.1128/AEM.02832-14.

 

Potential application of antimicrobial peptides in the treatment of bacterial biofilm infections. 

Strempel N, Strehmel J, Overhage J.

Curr Pharm Des. 2015;21(1):67-84. doi: 10.2174/1381612820666140905124312. Review.